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By: Wall Street Journal The Food and Drug Administration is planning to warn doctors about an interaction between the widely used breast-cancer drug tamoxifen and certain antidepressants after a study showed women on both drugs were more than twice as likely to see their cancer return. The study involved about 1,300 women and was released this past weekend at the American Society of Clinical Oncology's annual meeting in Orlando, Fla. Researchers found that women who were taking antidepressants like Paxil, Prozac and Zoloft along with tamoxifen for at least one year had a breast-cancer recurrence rate of 16% -- compared with a recurrence rate of 7.5% for women not taking the drugs. |
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Read more... [FDA to Cite Interaction Risk of Antidepressants, Tamoxifen]
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Paxil is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRI). Paxil intended purpose is to restore the balance of serotonin, a natural chemical in the brain, which may help to improve various mood issues. Paxil is used to treat depression, obsessive-compulsive disorder, anxiety disorders, post-traumatic stress disorder, and premenstrual dysphoric disorder. Paxil has a list of potential risks and side effects Serious Side Effects of Paxil
- Possible life-threatening serotonin syndrome when used with triptan medicines.
- Infant persistent pulmonary hypertension
- Suicidal thoughts or actions: Persons taking Paxil may be more likely to think about killing themselves or actually try to do so, especially when Paxil is first started or the dose is changed.
- Bleeding: Paxil may cause bleeding problems, especially if taken with aspirin, NSAIDs (nonsteroidal anti-inflammatory drugs, such as ibuprofen or naproxen), or other drugs that affect bleeding.
- Pregnancy: Babies delivered to mothers taking Paxil late in pregnancy have developed problems, such as difficulty breathing and feeding. Babies delivered to mothers taking Paxil early in pregnancy are sometimes born with heart problems.
- Sexual problems: You may have problems with impotence (erectile dysfunction), abnormal ejaculation, difficulty reaching orgasm, or decreased libido (sexual desire).
- Other minor side effects may include weakness, dry mouth, constipation, yawning, infection, diarrhea, sweating, dizziness, tremor, nervousness, nausea, difficulty sleeping, decreased appetite, and sleepiness.
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