On December 17, the FDA asked Pfizer to voluntarily suspend direct-to-consumer advertising on Celebrex during the time the FDA is obtaining and evaluating the new and conflicting scientific data on adverse effects associated with the drug. The FDA also requested Pfizer change the information provided to physicians to reflect the recommendations FDA made encouraging physicians to consider alternative therapies as they evaluate their individual patient needs. Pfizer agreed to suspend its Celebrex promotion and to craft appropriate detailing to physicians that reflects the uncertainty of scientific data currently available.

In addition to the serious side effects listed below, some common, but less serious side effects associated with Celebrex include:

• Headache
• Indigestion
• Upper respiratory tract infection (a "cold")
• Diarrhea
• Sinus inflammation
• Stomach pain
• Nausea

According to Pfizer, patients should not take Celebrex if they have aspirin-sensitive asthma, or allergic reactions to aspirin or other arthritis medicines or certain sulfa drugs called sulfonamides, or if they are in their third trimester of pregnancy.

Celebrex and other NSAID medicines can cause stomach ulcers that bleed. The chance of this serious problem increases the longer you take Celebrex and with higher doses of Celebrex. Stomach bleeding can also happen suddenly while you take Celebrex. Stop taking Celebrex and call your healthcare provider right away if you get:

• A burning stomach pain;
• Black bowel movements that look like tar;
• Vomit that looks like blood or coffee grounds.

Celebrex and other NSAID medicines can cause serious allergic reactions that include swelling of the face, lips, tongue or throat. These allergic reactions may cause problems with breathing, swallowing, and wheezing. Serious allergic skin reactions have also been reported with the use of NSAIDs. If you experience any of these symptoms, contact a physician immediately.